News

DTBE TB Emergency Drug Stockpile Now Accepting Requests

The CDC’s Division of Tuberculosis Elimination (DTBE) has activated its TB emergency drug stockpile. Currently available: Isoniazid 300 mg (30-count 
bottles), expiration 5/31/2026, inventory: 1,578 bottles.

Prioritization
• Directly funded programs with <150 cases: up to 50 bottles for first request
• ≥150 cases: up to 100 bottles for first request
• Additional requests: 50 bottles every 90 days

How to Request
1. Upload a signed request letter to GrantSolutions as a grant message
2. Address letter to your DTBE Project Officer and have the PI/PD sign it
3. Email the letter to your Project Officer and Neela Goswami

Requests must Include
• TB case burden (2023 data)
• Program performance (COT % from 2021 NTIP data; priority for ≥85%)
• Contact info and shipping address
• Quantity requested

WHO Approves Six AI Tools for TB Detection via Chest X-Rays

The World Health Organization (WHO) has approved six AI-powered software tools for detecting tuberculosis (TB) on chest X-rays. These computer-aided detection (CAD) tools are designed to support systematic TB screening in people aged 15 and older.
The approval follows a rigorous independent evaluation led by the Foundation for Innovative New Diagnostics (FIND) and reviewed by WHO’s Technical Advisory Group. While CAD tools have been recommended since 2021, this marks the first time six products have met WHO’s updated performance standards.

Note: A positive CAD result should always be confirmed with diagnostic testing before treatment begins.

WHO Updates Drug-Resistant TB Treatment Guidelines

The World Health Organization (WHO) has released an update to the Consolidated Guidelines on Tuberculosis (TB) - Module 4: Treatment and Care, with multiple novel 6- to 9-month regimens for multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB), which can be considered if there are barriers to use of the BPaLM regimen introduced in the last update.

Key Updates

• New 6-Month Regimen:  An all-oral, 6-month regimen composed of bedaquiline, delamanid, linezolid, levofloxacin and clofazimine (BDLLfxC) for treating MDR/RR-TB, including cases with additional resistance to fluoroquinolones (pre-XDR-TB).
• Modified 9-Month Regimens: Several potential 9-month regimens including bedaquiline, linezolid, moxifloxacin and pyrazinamide (BLMZ) are suggested as options for patients who are ineligible or who lack access to the 6-month regimens.
• New Two 4-month Regimens: A new regimen for the treatment of drug-susceptible tuberculosis (DS-TB), marking a significant advancement in TB care. This update formally includes two 4-month regimens for the treatment of drug-susceptible tuberculosis (DS-TB), marking a pivotal advancement in TB care.

This chapter incorporates recommendations that were made in 2022, based on new evidence that was available to WHO on the following: the use of the bedaquiline, pretomanid,  linezolid and moxifloxacin (BPaLM) regimen for patients with MDR/RR-TB, and the use of 9-month all-oral bedaquiline-containing regimens for patients with MDR/RR-TB. It also includes new recommendations developed in June 2024 based on new evidence from the BEAT Tuberculosis (BEAT-TB) and endTB trials.

Provisional 2024 Tuberculosis Data, United States

• Provisional 2024 Tuberculosis Data, United States | Tuberculosis Data | CDC

The CDC's provisional report on tuberculosis (TB) in the United States for 2024 reveals a slight increase in TB cases and rates compared to 2023.  
In 2024, 10,347 TB cases were reported, with a rate of 3.0 cases per 100,000 population, marking an 8% increase in case counts and a 6% increase in rates from the previous year. This rise is attributed to recovery from pandemic-related healthcare disruptions, increased travel, and outbreaks in several states.  

Despite these increases, most people in the U.S. remain at low risk for TB. The CDC emphasizes the importance of continued public health efforts to test and treat both TB disease and latent TB infection to prevent further spread and protect communities. 

Tuberculosis (TB) Treatment Guideline Updates

• Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline

The new tuberculosis (TB) treatment guidelines recommend a novel 4-month regimen for people with pulmonary TB and a shortened 4-month regimen for children with nonsevere TB. For drug-resistant TB, the updated regimens include bedaquiline, pretomanid, and linezolid, with or without moxifloxacin. These recommendations emphasize the use of all-oral, shorter treatment regimens for eligible individuals.

New NTCA Isolation Guidelines published in Clinical Infectious Diseases Journal

• Duration of Effective Tuberculosis Treatment, not Acid-Fast Bacilli (AFB) Smear Status, as the Determinant for Deisolation in Community Settings
• NTCA Guidelines for Respiratory Isolation and Restrictions to Reduce Transmission of Pulmonary TB in Community Settings

CDC Calendar

Follow this link to CDC's Calendar of tuberculosis related events.

Department of Health and Human Services Notices

• 2024 Technical Instructions for Tuberculosis (TB TIs) for Panel Physicians
• 2024 Technical Instructions (TB TIs) for Civil Surgeons

MMWR Releases

• March 2025 Case Finding Among and Comprehensive Management of Household Contacts of Persons with Pulmonary Tuberculosis: a Pilot Project — Uganda, 2023–2024
• June 2024 Progress Toward TB Elimination and TB Program Performance
• March 2024 Tuberculosis Preventive Treatment Update:  U.S. President's Emergency Plan for AIDS Relief 
• January 2024 Second Nationwide TB Outbreak Caused by Bone Allografts Containing Live Cells

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